|
|
|
|
|
|
|
||
The Journal of General Physiology, Vol 105, 661-676, Copyright © 1995 by The Rockefeller University Press
ARTICLES |
PS Jackson and K Strange
Department of Neurosurgery, Children's Hospital, Boston, Massachusetts 02115, USA.
Outwardly rectified, swelling-activated anion conductances have been described in numerous cell types. The major functional variable observed amongst these conductances is the extent and rate of depolarization-induced inactivation. In general, the conductances can be divided into two broad classes, those that show rapid inactivation in response to strong depolarization and those that show little or no voltage dependence. The swelling-activated anion conductance in rat C6 glioma cells is inactivated nearly completely by membrane depolarization above +90 mV and reactivated by membrane hyperpolarization. The kinetics of inactivation and reactivation are fit by single and double exponentials, respectively. Voltage-dependent behavior is well described by a simple linear kinetic model in which the channel exists in an open or one of three inactivated states. pH- induced changes in voltage-dependent gating suggest that the voltage sensor contains critical basic amino acid residues. Extracellular ATP blocks the channel in a voltage-dependent manner. The block is sensitive to the direction of net Cl- movement and increases open channel noise indicating that ATP interacts with the channel pore. Blockage of the channel with ATP dramatically slows depolarization- induced inactivation.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  E. K. Hoffmann, I. H. Lambert, and S. F. Pedersen Physiology of Cell Volume Regulation in Vertebrates Physiol Rev, January 1, 2009; 89(1): 193 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lambert and J. Oberwinkler Characterization of a proton-activated, outwardly rectifying anion channel J. Physiol., August 15, 2005; 567(1): 191 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ordaz, L. Vaca, R. Franco, and H. Pasantes-Morales Volume changes and whole cell membrane currents activated during gradual osmolarity decrease in C6 glioma cells: contribution of two types of K+ channels Am J Physiol Cell Physiol, June 1, 2004; 286(6): C1399 - C1409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Olsen, S. Schade, S. A. Lyons, M. D. Amaral, and H. Sontheimer Expression of Voltage-Gated Chloride Channels in Human Glioma Cells J. Neurosci., July 2, 2003; 23(13): 5572 - 5582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hisadome, T. Koyama, C. Kimura, G. Droogmans, Y. Ito, and M. Oike Volume-regulated Anion Channels Serve as an Auto/Paracrine Nucleotide Release Pathway in Aortic Endothelial Cells J. Gen. Physiol., May 13, 2002; 119(6): 511 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kolajova and J. M. Baltz Volume-Regulated Anion and Organic Osmolyte Channels in Mouse Zygotes Biol Reprod, April 1, 1999; 60(4): 964 - 972. [Abstract] [Full Text]
|
|
|
|
|
|
G. M. Dick, K. K. Bradley, B. Horowitz, J. R. Hume, and K. M. Sanders Functional and molecular identification of a novel chloride conductance in canine colonic smooth muscle Am J Physiol Cell Physiol, October 1, 1998; 275(4): C940 - C950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Droogmans, J. Prenen, J. Eggermont, T. Voets, and B. Nilius Voltage-dependent block of endothelial volume-regulated anion channels by calix[4]arenes Am J Physiol Cell Physiol, September 1, 1998; 275(3): C646 - C652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, S. Oiki, T. Tsumura, T. Shimizu, and Y. Okada Glibenclamide blocks volume-sensitive Cl- channels by dual mechanisms Am J Physiol Cell Physiol, August 1, 1998; 275(2): C343 - C351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Rutledge, M. Aschner, and H. K. Kimelberg Pharmacological characterization of swelling-induced D-[3H]aspartate release from primary astrocyte cultures Am J Physiol Cell Physiol, June 1, 1998; 274(6): C1511 - C1520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Monaghan, G. M. Mintenig, and F. V. Sepulveda Outwardly rectifying Cl- channel in guinea pig small intestinal villus enterocytes: effect of inhibitors Am J Physiol Gastrointest Liver Physiol, November 1, 1997; 273(5): G1141 - G1152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Braunstein, R. M. Roman, J. P. Clancy, B. A. Kudlow, A. L. Taylor, V. Gh. Shylonsky, B. Jovov, K. Peter, T. Jilling, I. I. Ismailov, et al. Cystic Fibrosis Transmembrane Conductance Regulator Facilitates ATP Release by Stimulating a Separate ATP Release Channel for Autocrine Control of Cell Volume Regulation J. Biol. Chem., February 23, 2001; 276(9): 6621 - 6630. [Abstract] [Full Text] [PDF]
|
|
|
|
