The Journal of General Physiology
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Published online May 12, 2008
doi:10.1085/jgp.200709924
The Journal of General Physiology, Vol. 131, No. 6, 575-587
The Rockefeller University Press, 0022-1295 $30.00
© 2008 Jia et al.
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ARTICLE

 NGF Inhibits M/KCNQ Currents and Selectively Alters Neuronal Excitability in Subsets of Sympathetic Neurons Depending on their M/KCNQ Current Background



Zhanfeng Jia1, Junjie Bei1, Lise Rodat-Despoix2, Boyi Liu1, Qingzhong Jia1, Patrick Delmas2, and Hailin Zhang1

1 Department of Pharmacology, Hebei Medical University, Shijiazhuang, China, 050017
2 CRN2M, CNRS, UMR 6231, Université de la Méditerranée, 13916 Marseille Cedex 20, France

Correspondence to Hailin Zhang: zhanghl{at}hebmu.edu.cn

M/KCNQ currents play a critical role in the determination of neuronal excitability. Many neurotransmitters and peptides modulate M/KCNQ current and neuronal excitability through their G protein–coupled receptors. Nerve growth factor (NGF) activates its receptor, a member of receptor tyrosine kinase (RTK) superfamily, and crucially modulates neuronal cell survival, proliferation, and differentiation. In this study, we studied the effect of NGF on the neuronal (rat superior cervical ganglion, SCG) M/KCNQ currents and excitability. As reported before, subpopulation SCG neurons with distinct firing properties could be classified into tonic, phasic-1, and phasic-2 neurons. NGF inhibited M/KCNQ currents by similar proportion in all three classes of SCG neurons but increased the excitability only significantly in tonic SCG neurons. The effect of NGF on excitability correlated with a smaller M-current density in tonic neurons. The present study indicates that NGF is an M/KCNQ channel modulator and the characteristic modulation of the neuronal excitability by NGF may have important physiological implications.

Z. Jia and J. Bei contributed equally to this work.

Abbreviations used in this paper: BFNC, benign familial neonatal convulsion; NGF, nerve growth factor; RTK, receptor tyrosine kinase; SCG, superior cervical ganglion; TTX, tetrodotoxin.


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 J. Cell Biol.Home page
Z. Jia, J. Bei, L. Rodat-Despoix, B. Liu, Q. Jia, P. Delmas, and H. Zhang
NGF Inhibits M/KCNQ Currents and Selectively Alters Neuronal Excitability in Subsets of Sympathetic Neurons Depending on their M/KCNQ Current Background
J. Cell Biol., June 16, 2008; 181(6): i21 - i21.
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