The Journal of General Physiology
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The Journal of General Physiology, Vol 22, 671-687, Copyright © 1939 by The Rockefeller University Press

ARTICLE

MEMBRANE AND PROTOPLASM RESISTANCE IN THE SQUID GIANT AXON

Kenneth S. Cole 1 and Alan L. Hodgkin 1

1 From the Department of Physiology, College of Physicians and Surgeons, Columbia University, New York, and The Marine Biological Laboratory, Woods Hole

The direct current longitudinal resistance of the squid giant axon was measured as a function of the electrode separation. Large sea water electrodes were used and the inter-electrode length was immersed in oil. The slope of the resistance vs. separation curve is large for a small electrode separation, but becomes smaller and finally constant as the separation is increased.

An analysis of the resistance vs. length curves gives the following results. The nerve membrane has a resistance of about 1000 ohm cm.2 The protoplasm has a specific resistance of about 1.4 times that of sea water. The resistance of the connective tissue sheath outside the fiber corresponds to a layer of sea water about 20µ in thickness. The characteristic length for the axon is about 2.3 mm. in oil and 6.0 mm. in sea water.

Accepted on January 11, 1939


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