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The Journal of General Physiology, Vol 25, 263-273, Copyright © 1941 by The Rockefeller University Press


ARTICLE

ANALYTICAL DIFFUSION OF INFLUENZA VIRUS AND MOUSE ENCEPHALOMYELITIS VIRUS

Jaques Bourdillon 1

1 From the Eldridge R. Johnson Foundation for Medical Physics, University of Pennsylvania, Philadelphia

Analytical diffusion has been applied to a study of influenza A virus in mouse lung, influenza A virus in the extra-embryonic fluids of the chick, and mouse encephalomyelitis virus in mouse brain.

The results from influenza in mouse lung suggested that about 99 per cent of the infectivity was present in particles 200 mµ in diameter, and 1 per cent in particles 6 mµ in diameter.

The results from influenza in extra-embryonic fluids indicated that the preparation was inhomogeneous and that the smallest virus units were about 6 mµ in diameter.

The results from mouse encephalomyelitis virus indicated that the preparation was also inhomogeneous, with 10 per cent of the infectivity in particles about 15 mµ in diameter.

It has been suggested that in virus preparations normal colloidal particles can act as carriers of much smaller virus units.

Submitted on June 21, 1941


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