The Journal of General Physiology
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The Journal of General Physiology, Vol 26, 11-16, Copyright © 1942 by The Rockefeller University Press

ARTICLE

THE ANTIGENICITY OF d-RIBONUCLEASE; THE INHIBITION OF THE ENZYME BY ITS HOMOLOGOUS IMMUNE SERUM

J. Smolens 1 and M. G. Sevag 1

1 From the Department of Bacteriology, The School of Medicine, University of Pennsylvania, Philadelphia

The enzyme d-ribonuclease is antigenic. Antisera, prepared by three different methods, reacted against antigen dilutions up to one million.

Apparently the homologous antiserum, when combined with the d-ribonuclease inhibited the activity of the enzyme from 10 to 30 per cent.

Submitted on May 28, 1942


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