The Journal of General Physiology
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The Journal of General Physiology, Vol 34, 75-79, Copyright © 1950 by The Rockefeller University Press

ARTICLE

TISSUE CULTURE STUDIES

V. ANALOGUES FOR NICOTINIC ACID



Wayne Hull 1, J. C. Perrone 1, and Paul L. Kirk 1

1 From the Division of Biochemistry, University of California Medical School, Berkeley

The use of acetyl-3-pyridine and pyridine-3-sulfonic acid as analogues for nicotinic acid has been tested with tissue cultures of embryonic chick heart. Both roller tube and Carrel flask cultures were employed. Cell migration, appearance of the cells, and the uptake of tracer P32 were used as criteria for the action of the analogues.

Migration of the cells could be inhibited by both compounds, but at different levels. Both produced abnormal types of cells, but not the same type of abnormality. Uptake of P32 was inhibited by both compounds. Addition of nicotinic acid failed to reverse the effects of the analogues at the concentrations used.

Submitted on May 8, 1950


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