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The Journal of General Physiology, Vol 35, 17-22, Copyright © 1951 by The Rockefeller University Press

ARTICLE

THE ACTION OF SOME HEMOLYSIS ACCELERATORS UPON LIPID AND PROTEIN MONOLAYERS

Helen L. Chen 1 and H. B. Collier 1

1 From the Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada

The effect of three accelerators of hemolysis—acetylphenylhydrazine, 9-aminoacridine, and phenothiazone—upon protein and lipid monolayers has been examined. These compounds, in low concentration, cause marked expansion of monolayers of plasma albumin, but have no apparent effect upon cholesterol films. It is suggested that these accelerators may affect the protein component of the erythrocyte membrane, thus enhancing the action of hemolytic agents.

Submitted on March 8, 1951


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