The Journal of General Physiology
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The Journal of General Physiology, Vol 35, 203-225, Copyright © 1951 by The Rockefeller University Press

ARTICLE

ON THE EFFECT OF COCAINE UPON SODIUM-DEFICIENT FROG NERVE

R. Lorente de Nó 1

1 From the Laboratories of The Rockefeller Institute for Medical Research

Cocaine diffuses through the epineurium with remarkable rapidity. The coefficient of diffusion of cocaine in the epineurium cannot be less than 0.44 x 10–4 cm.2/min.; it probably is not less than 1.22 x 10–4 cm.2/min.

Lack of sodium markedly sensitizes the nerve fibers to the anesthetic action of cocaine.

With sodium-deficient A fibers the action of cocaine develops in two phases. During the first phase cocaine substitutes for sodium and restores to A fibers the ability to conduct impulses; during the second phase cocaine produces anesthesia.

It is suggested that cocaine anesthetizes the nerve fibers through the sodium mechanism; i.e., by interfering with some of those chemical reactions in which, directly or indirectly, the internal sodium takes part.

Submitted on April 17, 1950


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