The Journal of General Physiology, Vol 35, 595-603,
Copyright © 1952 by The Rockefeller University Press
HEMOLYSIS CONSIDERED AS A PROGRESSIVE REACTION IN A HETEROGENEOUS SYSTEM
Eric Ponder 1 and
R. T. Cox 1
1 From The Nassau Hospital, Mineola, Long Island, and The Department of Physics, The Johns Hopkins University, Baltimore
It is demonstrated, without the use of special assumptions, that red cells are heterogeneous with respect to their resistance to at least certain lysins, that the reaction between the cell components and the lysin is virtually irreversible in some cases but reversible, although to different extents, in others, and that the lysin initiates a process in the cell which is not adequately described by the terms reversible and irreversible, but rather by the term progressive. Progressive reactions, i.e. reactions which cannot be stopped once they are well under way, may be looked for in systems which have structure, and in which local reactions occurring at strategic points lead to disproportionate results.
Submitted on July 31, 1951
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