The Journal of General Physiology
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The Journal of General Physiology, Vol 35, 841-846, Copyright © 1952 by The Rockefeller University Press

ARTICLE

THE INCORPORATION OF N15-GLYCINE BY AVIAN ERYTHROCYTES AND RETICULOCYTES IN VITRO

V. Allfrey 1 and A. E. Mirsky 1

1 From the Laboratories of The Rockefeller Institute for Medical Research

A study of the incorporation of glycine-N15 by chicken red cells in vitro has shown that:

1. There is no detectable nitrogen turnover in the histone or desoxyribonucleic acid of erythrocytes or reticulocytes.

2. Hemoglobin synthesis in the nucleated reticulocyte proceeds at 2 to 3 times the rate observed in the mature erythrocyte.

3. The uptake of glycine-N15 by heme is 9 to 14 times the corresponding uptake into hemoglobin, and 12 to 20 times the calculated uptake into globin.

4. Maturation of the red cell results in a decline in the rate of synthesis of both heme and globin, but the deceleration is much more marked in globin. synthesis.

5. No significant differences could be detected in the low N15 incorporations of nuclear and cytoplasmic hemoglobins.

Submitted on November 14, 1951


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