The Journal of General Physiology, Vol 37, 25-37,
Copyright © 1953 by The Rockefeller University Press
THE EFFECT OF SODIUM AND POTASSIUM IONS ON THE IMPEDANCE CHANGE ACCOMPANYING THE SPIKE IN THE SQUID GIANT AXON
Harry Grundfest 1,
Abraham M. Shanes 1, and
Walter Freygang 1
1 From the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda, and the Marine Biological Laboratory, Woods Hole
Decrease of the sodium concentration of the medium depresses both the spike and the associated impedance change in almost identical fashion. Elevation of the potassium level also depresses both phenomena, but affects the impedance change more than the spike; it slows the return to the initial impedance level. The effects on the threshold to brief square waves are also described. These results appear largely accounted for by the observations of Hodgkin and Huxley with the voltage clamp technique and by their recent hypothesis as to nature of the spike processes.
Submitted on February 16, 1953
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