The Journal of General Physiology
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The Journal of General Physiology, Vol 4, 573-584, Copyright © 1922 by The Rockefeller University Press

ARTICLE

EFFECT OF COCAINE ON THE GROWTH OF LUPINUS ALBUS. A CONTRIBUTION TO THE COMPARATIVE PHARMACOLOGY OF ANIMAL AND PLANT PROTOPLASM

David I. Macht 1 and Marguerite B. Livingston 1

1 From the Department of Pharmacology and the Laboratory of Plant Physiology, Johns Hopkins University, Baltimore.

1. The effects of cocaine and its decomposition products were studied on the growth of the young roots of Lupinus albus.

2. The results obtained were compared with similar experiments on animal tissues.

3. It was found that, while cocaine is the most toxic of these compounds studied for animal tissues, it was of comparatively low toxicity in respect to its effect on the growth of roots. On the other hand, sodium benzoate, being practically non-toxic for animals, was the most toxic of the compounds studied for the plant roots.

Submitted on March 7, 1922


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