The Journal of General Physiology
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The Journal of General Physiology, Vol 40, 135-145, Copyright © 1956 by The Rockefeller University Press

ARTICLE

CHANGES IN MEMBRANE CHARACTERISTICS OF HEART MUSCLE DURING INHIBITION

W. Trautwein 1, S. W. Kuffler 1, and C. Edwards 1

1 From The Wilmer Institute, The Johns Hopkins Hospital and University, Baltimore

Membrane characteristics were studied in isolated muscle strands from auricles of frogs using the "square pulse" technique. Changes in the time course and spatial spread of subthreshold electrotonic potentials were measured. If acetylcholine is applied in concentrations which cause slowing or stoppage of the heart beat, the following changes are produced: (a) the length constant (lambda) of the membrane is reduced, (b) the time constant is shortened. The effects are reversible and increase with acetylcholine concentration. The membrane changes caused by acetylcholine dimmish with time.

It is concluded that during acetylcholine inhibition, as well as during vagal inhibition, the conductance of the muscle membrane is increased. Appreciable changes in the resting membrane potential need not accompany inhibition.

Submitted on February 27, 1956


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W. G. Van der Kloot and B. Dane
Conduction of the Action Potential in the Frog Ventricle
Science, October 2, 1964; 146(3640): 74 - 75.
[Abstract] [PDF]


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