The Journal of General Physiology
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The Journal of General Physiology, Vol 40, 515-520, Copyright © 1957 by The Rockefeller University Press

ARTICLE

NARCOSIS AND EMULSION REVERSAL BY INERT GASES

Dewey F. Sears 1 and Wallace O. Fenn 1

1 From the Department of Physiology, The University of Rochester School of Medicine and Dentistry, Rochester, New York

Investigations of the effect of high pressures of Na (100 to 130 atmospheres) and of Ar (60 to 80 atmospheres) showed that these gases are effective in reversing the phases of an oil in water emulsion. Nitrous oxide did not cause reversal at pressures as high as 53 atmospheres nor did helium as high as 107 atmospheres. We found CO2 most effective in reversing the emulsions and attributed this to its chemical properties. It is suggested that these observations may help to explain the narcotic effects of inert gases.

Submitted on October 30, 1956


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H. R. Schreiner, R. C. Gregoire, and J. A. Lawrie
New Biological Effect of the Gases of the Helium Group
Science, May 18, 1962; 136(3516): 653 - 654.
[Abstract] [PDF]


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