The Journal of General Physiology
Cell MicroControls
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The Journal of General Physiology, Vol 40, 547-563, Copyright © 1957 by The Rockefeller University Press

ARTICLE

ADAPTATION OF BACILLUS MEGATHERIUM TO TERRAMYCIN (OXYTETRACYCLINE)

John H. Northrop 1 and With the Technical Assistance of Marie King

1 From the Laboratory of The Rockefeller Institute for Medical Research, Department of Bacteriology, University of California, Berkeley

B. megatherium cultures contain a few cells per hundred million which are able to grow in the presence of terramycin. Growth of the other cells is inhibited by the antibiotic with the result that the resistant cells overgrow the culture. The resistant cells are present in the culture, without contact with terramycin, and are able to grow in the presence of terramycin, without further modification.

The resistant cells are mutants of sensitive cells.

Submitted on September 10, 1956


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