The Journal of General Physiology
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The Journal of General Physiology, Vol 41, 233-242, Copyright © 1957 by The Rockefeller University Press

ARTICLE

XANTHINE OXIDASE ACTIVITY IN REGENERATING LIVER

Muriel Feigelson 1, Philip Feigelson 1, and Paul R. Gross 1

1 From the Department of Biochemistry, College of Physicians and Surgeons, Columbia University, and the Department of Biology, New York University, New York

The xanthine oxidase activity of mouse regenerating liver has been shown to be elevated during the period of rapid liver growth and proliferation. This increase is evident when the enzyme activity is expressed per unit wet tissue weight, per unit nitrogen, or per cell. The adrenal cortex probably plays only a minor role in implementing this phenomenon. Further augmentation of the xanthine oxidase level of regenerating liver is not induced by the administration of large quantities of the substrate, xanthine, to the animal.

Submitted on May 20, 1957


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