The Journal of General Physiology
Sign up for e-mail content alerts
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article
Right arrow PDF (Full Text)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JGP
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kedem, O.
Right arrow Articles by Katchalsky, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kedem, O.
Right arrow Articles by Katchalsky, A.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of General Physiology, Vol 45, 143-179, Copyright © 1961 by The Rockefeller University Press


ARTICLE

A Physical Interpretation of the Phenomenological Coefficients of Membrane Permeability

O. Kedem 1 and A. Katchalsky 1

1 From the Weizmann Institute of Science, Rehovoth, Israel

A "translation" of the phenomenological permeability coefficients into friction and distribution coefficients amenable to physical interpretation is presented. Expressions are obtained for the solute permeability coefficient omega and the reflection coefficient sigma for both non-electrolytic and electrolytic permeants. An analysis of the coefficients is given for loose membranes as well as for dense natural membranes where transport may go through capillaries or by solution in the lipoid parts of the membrane. Water diffusion and filtration and the relation between these and capillary pore radius of the membrane are discussed. For the permeation of ions through the charged membranes equations are developed for the case of zero electrical current in the membrane. The correlation of sigma with omega and Lp for electrolytes resembles that for non-electrolytes. In this case omega and sigma depend markedly on ion concentration and on the charge density of the membrane. The reflection coefficient may assume negative values indicating anomalous osmosis. An analysis of the phenomena of anomalous osmosis was carried out for the model of Teorell and Meyer and Sievers and the results agree with the experimental data of Loeb and of Grim and Sollner. A set of equations and reference curves are presented for the evaluation of omega and sigma in the transport of polyvalent ions through charged membranes.

Submitted on December 9, 1960


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
Am. J. Physiol. Cell Physiol.Home page
P.-h. G. Chao, A. C. West, and C. T. Hung
Chondrocyte intracellular calcium, cytoskeletal organization, and gene expression responses to dynamic osmotic loading
Am J Physiol Cell Physiol, October 1, 2006; 291(4): C718 - C725.
[Abstract] [Full Text] [PDF]


Home page
ScienceHome page
R. S. Norman
Water Salination: A Source of Energy
Science, October 25, 1974; 186(4161): 350 - 352.
[Abstract] [PDF]


Home page
ScienceHome page
E. H. Bresler, R. P. Wendt, and E. A. Mason
Steady-State Sieving across Membranes
Science, May 21, 1971; 172(3985): 858 - 859.
[Abstract] [PDF]


Home page
ScienceHome page
J. N. Weinstein and S. R. Caplan
Charge-Mosaic Membranes: Enhanced Permeability and Negative Osmosis with a Symmetrical Salt
Science, July 5, 1968; 161(3836): 70 - 72.
[Abstract] [PDF]



  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents