The Journal of General Physiology
Avanti Polar Lipids
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The Journal of General Physiology, Vol 49, 641-653, Copyright © 1966 by The Rockefeller University Press

ARTICLE

Cat Heart Muscle in Vitro

IX. Cell ion and water contents in anisosmolal solutions



Ernest Page 1 and S. R. Storm 1

1 From the Biophysical Laboratory, Harvard Medical School, Boston.

Dr. Page's present address is the Departments of Medicine and Physiology, University of Chicago

Cell contents of water, K, Na, and Cl have been determined in cat right ventricular papillary muscles immersed in solutions with and without NaCl when the external osmolality was varied with sucrose. The plot of cell water/kilogram dry weight (corrected for sucrose content) vs. (external osmolality)-1 suggests that not less than 82% of water present in cells at physiological external osmolality is free to move across the cell membrane in response to an imposed osmotic gradient. Cells fail to increase their water content in very hypotonic solutions. For osmolalities greater than 5 times isosmolal, at which the mannitol space and the Cl36 space are both equal to 100% of muscle water, rather large amounts of univalent cation appear to remain "bound" to the tissue.

Submitted on March 29, 1965


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