The Journal of General Physiology
Axon Instruments microelectrode amplifiers
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The Journal of General Physiology, Vol 49, 781-791, Copyright © 1966 by The Rockefeller University Press

ARTICLE

The Ionic Dependence of Cardiac Excitability and Contractility

Allan J. Brady 1 and S. T. Tan 1

1 From the Los Angeles County Heart Association Cardiovascular Research Laboratory, The University of California at Los Angeles

In contrast to the large volume of data supporting the dependence of cardiac excitability and phasic contractility on external Na, Van der Kloot and Rubin (1962) and Singh (1962) have reported the persistence of both electrical and phasic mechanical activity in frog atrial and ventricular preparations soaked in isotonic sucrose solutions. The acute ionic dependence of excitability and contractility in small frog atrial trabeculae has been investigated with the conclusion that excitability and phasic contractions may continue for extended periods of time in sucrose media if the extracellular ionic concentrations remain above 2% of normal. This behavior is attributed to the slow exchange properties of the cell surfaces of the frog cardiac trabeculae and the antagonistic effects of Na, K, and Ca ions on both membrane excitability and fiber contractility.

Submitted on August 4, 1965


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