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The Journal of General Physiology, Vol 49, 793-806, Copyright © 1966 by The Rockefeller University Press

ARTICLE

Differences in Na and Ca Spikes As Examined by Application of Tetrodotoxin, Procaine, and Manganese Ions

Susumu Hagiwara 1 and Shigehiro Nakajima 1

1 From the Department of Zoology and Brain Research Institute, University of California at Los Angeles.

Dr. Hagiwara's present address is the Marine Neurobiology Facility and Department of Marine Biology, Scripps Institution of Oceanography, University of California at San Diego, La Jolla. Dr. Nakajima's present address is the Department of Physiology, Juntendo University, Medical College, Bunkyo-ku, Tokyo, Japan

The effects of tetrodotoxin, procaine, and manganese ions were examined on the Ca spike of the barnacle muscle fiber injected with Ca-binding agent as well as on the action potential of the ventricular muscle fiber of the frog heart. Although tetrodotoxin and procaine very effectively suppress the "Na spike" of other tissues, no suppressing effects are found on "Ca spike" of the barnacle fiber, while the initiation of the Ca spike is competitively inhibited by manganese ions. The initial rate of rise of the ventricular action potential is suppressed by tetrodotoxin and procaine but the plateau phase of the action potential is little affected. In contrast the suppressing effect of manganese ions is mainly on the plateau phase. The results suggest that the plateau phase of the ventricular action potential is related to the conductance increase in the membrane to Ca ions even though Na conductance change may also contribute to the plateau.

Submitted on June 21, 1965


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