The Journal of General Physiology, Vol 49, 171-178,
Copyright © 1966 by The Rockefeller University Press
On the Internal Structure of Bacteriophage Lambda
A. D. Kaiser 1
1 From the Department of Biochemistry, Stanford University School of Medicine, Palo Alto
The structure of bacteriophage lambda has been studied by electron microscopy of negatively stained particles. The phage particles will eject their DNA if they are heated or dialyzed against a chelating agent. The ghost particles, so formed, have a channel running down their tails. Since the channel is not visible in normal particles, the channel may be filled with part of the DNA molecule. Up to 30% of the ghosts contain round objects about half the internal diameter of the head. The round objects, called "cores," have the same buoyant density as the coat protein. The core may be a protein spool about which the phage DNA is wound.
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