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The Journal of General Physiology, Vol 49, 183-196, Copyright © 1966 by The Rockefeller University Press

GENETIC TRANSFORMATION

On the Mechanism of Integration of Transforming Deoxyribonucleate

Maurice S. Fox 1

1 From the Department of Biology, Massachusetts Institute of Technology, Cambridge

The characteristics of the intermediates in the reaction, between DNA and pneumococcus, that results in genetic transformation are described in so far as they have been characterized. Transformation with DNA isolated from bacteria carrying in addition to genetic markers 32P as a radioactive label and 2H and 15N as density labels has permitted the characterization of the product of recombination between the newly introduced DNA and the DNA of a recipient bacterium. The evidence for a single strand displacement mechanism producing a hybrid structure in the DNA of the recipient bacteria is presented. Progeny of single transformants have been examined. The results of these segregation studies permit the further characterization of this hybrid product of transformation as a genetically heterozygous structure.


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