The Journal of General Physiology
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The Journal of General Physiology, Vol 50, 423-445, Copyright © 1966 by The Rockefeller University Press

ARTICLE

Osmometrically Determined Characteristics of the Cell Membrane of Squid and Lobster Giant Axons

Alan R. Freeman 1, John P. Reuben 1, Philip W. Brandt 1, and Harry Grundfest 1

1 From the Laboratory of Neurophysiology, Department of Neurology and Department of Anatomy, College of Physicians and Surgeons, Columbia University, New York, and the Marine Biological Laboratory, Woods Hole, Massachusetts.

Dr. Freeman's present address is the Department of Physiology, Rutgers University Medical School, New Brunswick, New Jersey

Lobster and squid giant nerve fibers respond differently when subjected to osmotic challenges. The axons proper, as distinct from the total (fiber) complex formed by the axon and connective sheath, both behave as "fast" osmometers for changes in the concentration of NaCl, but the maximum degree of swelling in hyposmotic media is by about 60% in lobster and only by 20% in squid. The relative volume intercepts of the van't Hoff relation are about 0.2 for lobster and 0.4 for squid. The sheaths of both axons undergo only small, apparently passive changes in volume. Lobster axons are permeable to Cl, but squid axons are impermeable to this anion. Lobster axons are also permeable to glycerol. The implications of the data as to the nature of volume regulation of cells are discussed.

Submitted on January 27, 1966


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[Abstract] [PDF]


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