The Journal of General Physiology
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The Journal of General Physiology, Vol 51, 369-384, Copyright © 1968 by The Rockefeller University Press


ARTICLE

The Dynamic Properties of Mammalian Skeletal Muscle

Alan S. Bahler 1, John T. Fales 1, and Kenneth L. Zierler 1

1 From the Departments of Biomedical Engineering, Environmental Medicine, and Medicine, The Johns Hopkins University and Hospital, Baltimore, Maryland 21205.

Dr. Bahler's present address is the Department of Electrical Engineering and Bioengineering Laboratory, Rice University, Houston, Texas 77001

The dynamic characteristics of the rat gracilis anticus muscle at 17.5°C have been determined by isotonic and isometric loading. For a fixed initial length these characteristics were represented either as a family of length-velocity phase trajectories at various isotonic afterloads or as a series of force-velocity curves at different lengths. An alternate method of viewing these data, the length-external load-velocity phase space, was also generated. When the muscle was allowed to shorten from different initial lengths, the velocity of shortening achieved at a given length was lower for longer initial lengths. The amount of departure was also dependent upon the isotonic load, the greater the load the greater the departure. The departures were not caused by changes in the elastic elements of the muscle or fatigue in the ordinary sense. When the behavior of the muscle was investigated at different frequencies of stimulation, the shortening velocity was a function of the number of stimulating pulses received by the muscle at a given frequency. The shortening velocity of the rat gracilis anticus muscle is, therefore, not only a function of load and length, but also of an additional variable related to the time elapsed from onset of stimulation.

Submitted on April 6, 1967


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