The Journal of General Physiology
Axon Instruments microelectrode amplifiers
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The Journal of General Physiology, Vol 51, 635-654, Copyright © 1968 by The Rockefeller University Press

ARTICLE

Effects of Lithium on Different Membrane Components of Crayfish Stretch Receptor Neurons

Shosaku Obara 1 and Harry Grundfest 1

1 From the Laboratory of Neurophysiology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032.

Dr. Obara's present address is the Department of Anatomy, Albert Einstein College of Medicine, Bronx, New York 10461

Unlike several other varieties of input membrane, that of the crayfish stretch receptor develops a generator potential in response to stretch when all the Na of the medium is replaced with Li. However, Li depolarizes the receptor neuron, the soma membrane becoming more depolarized than that of the axon. During exposure to Li the cell usually fires spontaneously for a period, and when it becomes quiescent spike electrogenesis fails in the soma but persists in the axon. These effects are seen in the rapidly adapting as well as the slowly adapting cells. The block of spike electrogenesis of the soma membrane is only partly due to the Li-induced depolarization and a significant role must be ascribed to a specific effect of Li.

Submitted on October 30, 1967


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