|
|
|
|
|
|
|
||
ARTICLE |
Dr. Bittner's present address is Department of Anatomy, Brain Research Institute, University of California, at Los Angeles, Los Angeles, California 90024
Junctional potentials (jp's) recorded from superficial distal fibers of the crayfish opener muscle are up to 50 times larger than jp' in superficial central fibers when the single motor axon that innervates the muscle is stimulated at a frequency of 1/sec or less. At 80/sec, in contrast, central jp's are up to four times larger than those observed in distal fibers. The tension produced by single muscle fibers of either type is directly proportional to the integral of the time-voltage curve minus an excitation-contraction coupling threshold of 3 mv. Distal fibers therefore produce almost all the total muscle tension at low frequencies of stimulation and central fibers add an increasingly greater contribution as their nerve endings begin to facilitate in response to increased rate of motor discharge. Differentiation of muscle membrane characteristics (input resistance, space constant, time constant) cannot account for these differences in facilitation ratios. The mechanism of neuronal differentiation is not based upon the size or effectiveness of transmitter quanta, since equal sized jp's have equal variances;: mjp sizes and variances are also equal. No differences were found between fiber types in rates of transmitter mobilization, density of innervation, or the relationship between transmitter release and terminal depolarization. Single terminals on distal fibers were found to release transmitter with a greater probability than central terminals. More effective invasion of distal terminals by the nerve impulse at low frequencies can account for the difference.
Submitted on October 30, 1967
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Diaz-Rios and M. W. Miller Target-Specific Regulation of Synaptic Efficacy in the Feeding Central Pattern Generator of Aplysia: Potential Substrates for Behavioral Plasticity? Biol. Bull., June 1, 2006; 210(3): 215 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Stein, C. R. Smarandache, M. Nickmann, and U. B. S. Hedrich Functional consequences of activity-dependent synaptic enhancement at a crustacean neuromuscular junction J. Exp. Biol., April 1, 2006; 209(7): 1285 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. DeMill and K. R. Delaney Interaction between facilitation and presynaptic inhibition at the crayfish neuromuscular junction J. Exp. Biol., June 1, 2005; 208(11): 2135 - 2145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Millar, R. S. Zucker, G. C. R. Ellis-Davies, M. P. Charlton, and H. L. Atwood Calcium Sensitivity of Neurotransmitter Release Differs at Phasic and Tonic Synapses J. Neurosci., March 23, 2005; 25(12): 3113 - 3125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mykles, S. Medler, A. Koenders, and R. Cooper Myofibrillar protein isoform expression is correlated with synaptic efficacy in slow fibres of the claw and leg opener muscles of crayfish and lobster J. Exp. Biol., February 15, 2002; 205(4): 513 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Rathmayer, S. Djokaj, A. Gaydukov, and S. Kreissl The Neuromuscular Junctions of the Slow and the Fast Excitatory Axon in the Closer of the Crab Eriphia spinifrons Are Endowed with Different Ca2+ Channel Types and Allow Neuron-Specific Modulation of Transmitter Release by Two Neuropeptides J. Neurosci., February 1, 2002; 22(3): 708 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Crider and R. L. Cooper Differential facilitation of high- and low-output nerve terminals from a single motoneuron J Appl Physiol, March 1, 2000; 88(3): 987 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Quigley, M. Msghina, C. K. Govind, and H. L. Atwood Visible Evidence for Differences in Synaptic Effectiveness With Activity-Dependent Vesicular Uptake and Release of FM1-43 J Neurophysiol, January 1, 1999; 81(1): 356 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Hua, D. A. Raciborska, W. S. Trimble, and M. P. Charlton Different VAMP/Synaptobrevin Complexes for Spontaneous and Evoked Transmitter Release at the Crayfish Neuromuscular Junction J Neurophysiol, December 1, 1998; 80(6): 3233 - 3246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. V. Hill and P. Jin Regulation of Synaptic Depression Rates in the Cricket Cercal Sensory System J Neurophysiol, March 1, 1998; 79(3): 1277 - 1285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Msghina, C. K. Govind, and H. L. Atwood Synaptic Structure and Transmitter Release in Crustacean Phasic and Tonic Motor Neurons J. Neurosci., February 15, 1998; 18(4): 1374 - 1382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. FITZSIMONDS and M.-M. POO Retrograde Signaling in the Development and Modification of Synapses Physiol Rev, January 1, 1998; 78(1): 143 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mar and P. Drapeau Modulation of Conduction Block in Leech Mechanosensory Neurons J. Neurosci., July 15, 1996; 16(14): 4335 - 4343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. L. Atwood, F. Lang, and W. A. Morin Synaptic Vesicles: Selective Depletion in Crayfish Excitatory and Inhibitory Axons Science, June 23, 1972; 176(4041): 1353 - 1355. [Abstract] [PDF]
|
|
|
|
|
|
R. G. Sherman and H. L. Atwood Synaptic Facilitation: Long-Term Neuromuscular Facilitation in Crustaceans Science, March 26, 1971; 171(3977): 1248 - 1250. [Abstract] [PDF]
|
|
|
|
|
|
J. Bruner and D. Kennedy Habituation: Occurrence at a Neuromuscular Junction Science, July 3, 1970; 169(3940): 92 - 94. [Abstract] [PDF]
|
|
|
|
|
|
B. Peretz Central Neuron Initiation of Periodic Gill Movements Science, November 28, 1969; 166(3909): 1167 - 1172. [Abstract] [PDF]
|
|
|
|
