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The Journal of General Physiology, Vol 52, 240-257, Copyright © 1968 by The Rockefeller University Press

ARTICLE

Sodium Movements in Perfused Squid Giant Axons

Passive fluxes



Eduardo Rojas 1 and Mitzy Canessa-Fischer 1

1 From the Laboratorio de Biofísica, Facultad de Ciencias, Universidad de Chile, Clasificador 198, Correo Central, Santiago, Chile

Sodium movements in internally perfused giant axons from the squid Dosidicus gigas were studied with varying internal sodium concentrations and with fluoride as the internal anion. It was found that as the internal concentration of sodium was increased from 2 to 200 mM the resting sodium efflux increased from 0.09 to 34.0 pmoles/cm2sec and the average resting sodium influx increased from 42.9 to 64.5 pmoles/cm2sec but this last change was not statistically significant. When perfusing with a mixture of 500 mM K glutamate and 100 mM Na glutamate the resting efflux was 10 ± 3 pmoles/cm2sec and 41 ± 10 pmoles/cm2sec for sodium influx. Increasing the internal sodium concentration also increased both the extra influx and the extra efflux of sodium due to impulse propagation. At any given internal sodium concentration the net extra influx was about 5 pmoles/cm2impulse. This finding supports the notion that the inward current generated in a propagated action potential can be completely accounted for by movements of sodium.

Submitted on August 3, 1967


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