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The Journal of General Physiology, Vol 53, 298-310, Copyright © 1969 by The Rockefeller University Press

ARTICLE

Action Potentials, Afterpotentials, and Excitation-Contraction Coupling in Frog Sartorius Fibers without Transverse Tubules

Peter W. Gage 1 and Robert S. Eisenberg 1

1 From the Department of Physiology, Duke University, Durham, North Carolina 27706.

Dr. Gage's present address is Department of Physiology, University of New South Wales, Kensington, Australia. Dr. Eisenberg's present address is Department of Physiology, University of California at Los Angeles, Los Angeles, California 90024

In frog sartorius muscle fibers in which the transverse tubular system has been disrupted by treatment with glycerol, action potentials which are unaccompanied by twitches can be recorded. These action potentials appear to be the same as those recorded in normal fibers except that the early afterpotential usually consists of a small hyperpolarization of short duration. After a train of action potentials no late afterpotential is seen even when the membrane potential is changed from the resting level. In fibers without transverse tubules hyperpolarizing currents do not produce a creep in potential. The interruption of excitation-contraction coupling, the changes in the afterpotentials, and the disappearance of creep are all attributed to the lack of a transverse tubular system.

Submitted on October 25, 1968


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