The Journal of General Physiology
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The Journal of General Physiology, Vol 81, 195-211, Copyright © 1983 by The Rockefeller University Press

ARTICLES

Regulation of calcium sensitivity in perforated mammalian cardiac cells

A Weisberg, G McClellan, M Tucker, LE Lin and S Winegrad

Sarcolemmal perforations can be produced in bundles of rat right ventricular cells by either perfusion of the heart or soaking of the bundles with a solution containing 10 mM EGTA. All cells are affected and lose approximately 40% of the surface membrane. In these cells it is possible to show cAMP regulation of contractility (maximum Ca- activated force) without cAMP regulation of Ca sensitivity (pCa for 50% of maximum Ca-activated force). Therefore, the target molecule for cAMP is different for the two regulatory systems. Both regulatory systems can be slowly washed out of the cell by 10 mM EGTA solution but not by relaxing or contraction solutions. A model for regulation of Ca sensitivity is proposed.
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