|
|
|
|
|
|
|
||
The Journal of General Physiology, Vol 89, 405-420, Copyright © 1987 by The Rockefeller University Press
ARTICLES |
TE Decoursey, KG Chandy, S Gupta and MD Cahalan
Using gigohm-seal recording, we studied ion channel expression in resting and activated T lymphocytes from mice. Both the number of channels per cell and the predominant type of K+ channel depend upon the state of activation of the cell. Unstimulated T cells express small numbers of K+ channels, typically a dozen per cell, and are heterogeneous, usually expressing either type n or type l K+ channels (see DeCoursey, T. E., K. G. Chandy, S. Gupta, and M. D. Cahalan. 1987. Journal of General Physiology. 89:379-404). 1 d after stimulation by the murine T cell mitogen concanavalin A, large numbers of type n K+ channels appear in enlarged, activated cells. Type n channels appear in activated cells with a time course consistent with that reported for mitogen-induced enhancement of protein synthesis. Voltage-gated tetrodotoxin-sensitive Na+ channels present in about one-third of unstimulated cells from the MRL-n strain are increased approximately 10- fold after activation.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Beeton and K. G. Chandy Potassium Channels, Memory T Cells, and Multiple Sclerosis Neuroscientist, December 1, 2005; 11(6): 550 - 562. [Abstract] [PDF]
|
|
|
|
 |
|
 P. A. Koni, R. Khanna, M. C. Chang, M. D. Tang, L. K. Kaczmarek, L. C. Schlichter, and R. A. Flavell Compensatory Anion Currents in Kv1.3 Channel-deficient Thymocytes J. Biol. Chem., October 10, 2003; 278(41): 39443 - 39451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-H. Liu, B. K. Fleischmann, B. Hondowicz, C. C. Maier, L. A. Turka, K. Yui, M. I. Kotlikoff, A. D. Wells, and B. D. Freedman Modulation of Kv Channel Expression and Function by TCR and Costimulatory Signals during Peripheral CD4+ Lymphocyte Differentiation J. Exp. Med., October 7, 2002; 196(7): 897 - 909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Miller, S. H. Wei, I. Parker, and M. D. Cahalan Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node Science, June 7, 2002; 296(5574): 1869 - 1873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. McCormack, K. McCormack, M. S. Nadal, E. Vieira, A. Ozaita, and B. Rudy The Effects of Shaker beta -Subunits on the Human Lymphocyte K+ Channel Kv1.3 J. Biol. Chem., July 16, 1999; 274(29): 20123 - 20126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Eder Ion channels in microglia (brain macrophages) Am J Physiol Cell Physiol, August 1, 1998; 275(2): C327 - C342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, B. Xu, R. E. White, and L. Lu Growth factor-mediated K+ channel activity associated with human myeloblastic ML-1 cell proliferation Am J Physiol Cell Physiol, November 1, 1997; 273(5): C1657 - C1665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Felzen, R. Lavy, M. Garcia, G. Berke, P. Gardner, and O. Binah Interaction of Cytotoxic T Lymphocytes and Guinea Pig Ventricular Myocytes : Pharmacological Modulation by Blocking K+ Currents in Cytotoxic T Lymphocytes Circ. Res., February 1, 1996; 78(2): 253 - 261. [Abstract] [Full Text]
|
|
|
|
|
|
R. Lewis and M. Cahalan Subset-specific expression of potassium channels in developing murine T lymphocytes Science, February 12, 1988; 239(4841): 771 - 775. [Abstract] [PDF]
|
|
|
|
|
|
S. Ghanshani, H. Wulff, M. J. Miller, H. Rohm, A. Neben, G. A. Gutman, M. D. Cahalan, and K. G. Chandy Up-regulation of the IKCa1 Potassium Channel during T-cell Activation. MOLECULAR MECHANISM AND FUNCTIONAL CONSEQUENCES J. Biol. Chem., November 17, 2000; 275(47): 37137 - 37149. [Abstract] [Full Text] [PDF]
|
|
|
|
