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FIGURE 5. Reconstruction of t-BuBHQ-induced [Ca2+]i transients and their modification by caffeine and ryanodine. Simulated effects of sudden inhibition of ER Ca2+ uptake on ci ( [Ca2+]i, A), JRelease (B), and intraluminal Ca2+ concentration, cER ( ). Simulations were performed as described in APPENDIX B using experimentally determined descriptions of  i from Fig. 1 D, JSERCA from Fig. 2 C, and PER(vi/vERER) from Fig. 4 D. Jpm was described by smooth curves obtained from analysis of individual cells from Fig. 4 as in Fig. 3 C, with initial values of ci based on estimates of resting [Ca2+]i in those same cells. Insets in A and B show simulations performed assuming a fixed initial value (50 nM) for ci.
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