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Cover picture: Minimum model of GAT1 (GABA:Na+:Cl-) cotransport fluiction. The transporter exits primarily in two states, Eout and Ein, and transitions between them take place through the transitional states, *Eout and *Ein. Substrate binding reactions are at equilibrium within each state, and each transition depends on the occupancy (+) or vacancy (-) of binding sites given in a box. See related article by Hilgemann, D.W., and C.C. Lu, in this issue, pp. 459-475.
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