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The Journal of General Physiology 116 5 Cover picture: A functional consisting of ryanodine receptor, N-type Ca²⁺ channel and BK channel in bullfrog sympathetic neurons. BK Channels sense the Ca²⁺ ([Ca²⁺]_BK) in the Ca²⁺ microdomain ([Ca²⁺]_D) created by N-type Ca²⁺ channels and ryanodine receptors, while SK channels sense a Ca²⁺ ([Ca²⁺]_SK) remote from the Ca²⁺ microdomain. See related article by Akita, T., and K. Kuba, in this issue, pp. 697-720.

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