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The Journal of General Physiology 117 4 Cover picture: The Na,K-ATPase or 3 Na⁺/2 K⁺ pump cycles through four stages, with interlocking alternations of conformation (E₁/E₂) and of phosphorylation/ dephosphorylation and ion binding/occlusion and deocclusion/release reactions. The major current-carrying step, Na⁺ deocclusion/release (forward) or rebinding/reocclusion (reverse), gives backward-running pumps an S-shaped voltage dependence whose midpoint is determined by [Na⁺]. See related article by De Weer, P., D.C. Gadsby, and Rakowski, in this issue, pp. 315­328.

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