About the Cover
The Journal of General Physiology
118
6
Cover picture:The receptor-regulated signaling pathway of bacterial chemotaxis. The homodimeric, a-helical chemoreceptor serves as the structural framework for the assembly of a supermolecular complex containing the adaptation enzymes CheB/CheR, the kinases CheA/CheY, and the coupling protein CheW. Attractant binding to the receptor periplasmic domain inhibits kinase activity, whereas covalent modification of the cytoplasmic adaptation sites stimulates kinase activity. See related article by Bornhorst, J.A., and J.J. Falke, in this issue, pp. 693-710.
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