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The Journal of General Physiology 119 1 Cover picture:Possible mechanism for the interaction Mg²⁺ and Ca²⁺ ions and the domain peptide DP4 of the ryanodine receptor (RyR) in the activation of the RyR Ca²⁺ release channel that initiates a Ca²⁺ spark in a permeabilized skeletal muscle fiber. See related article by Shtifman, A., C.W. Ward, T. Yamamoto, J. Wang, B. Oblinsky, H.H. Valdivia, N. Ikemoto, and M.F. Schneider in this issue, pp. 15-31.

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