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COVER PICTURE: The entry of Na+ into rat taste receptor cells (TRCs) through apical Na+ channels (ENaCs) depolarizes TRCs, leading to neural responses resulting in the perception of sodium salt taste. Acids also enter TRCs and inhibit Na+ entry through ENaCs, which decreases the neural responses to NaCl. In contrast, alkaline pH enhances Na+ entry into TRCs and increases the neural response to NaCl. See related article by Lyall, V., R.I. Alam, T.-H. Phan, O.F. Russell, S.A. Malik, G.L. Heck, and J.A. DeSimone 793-815.)
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