About the Cover
COVER PICTURE: Effect of titin degradation on cardiac myocyte calcium sensitivity. Tracings show sarcomere length shortening with exposure to increasing [Ca11] for a skinned cardiac myocyte, before (black) and after (gray) mild trypsin digestion (top). Micrographs: after titin degradation exposure to pCa 5.4 leads to rapid, irreversible hypercontraction (bottom). See related article by Helmes, M., C.C. Lim, R. Liao, A. Bharti, L. Cui, and D.B. Sawyer in this issue, 97-110.)
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