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COVER PICTURE: Cyclic AMP stimulates exocytosis in insulin-producing cells by both PKA-dependent and PKA-independent pathways. The PKA-independent action of cAMP is lost in mice lacking the sulfonylurea receptor protein SUR1, which could indicate that SUR1, the cAMP effector protein cAMP-GEFII, and other proteins that regulate exocytosis form a protein network, which influences the release competence of the secretory granules. Thus, SUR1 may have cellular functions in addition to being merely a subunit of the ATP-regulated K1-channel. See related article by Eliasson, L., X. Ma, E. Renstr–m, S. Barg, P.-O. Berggren, J. Galvanovskis, J. Gromada, X. Jing, I. Lundquist, A. Salehi, S. Sewing, and P. Rorsman in this issue, pp. 181-197.)
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