The Journal of General Physiology
World Precision Insruments
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COVER PICTURE: The willing-reluctant mechanism for G-protein modulation of voltage-gated calcium channels is a prototypic paradigm for state-dependent ligand (G) regulation of ion channels. The manifestations of this mechanism are therefore strikingly diverse at various voltages, so practical synthesis of the entire behavioral spectrum via compound-state analysis deepens understanding of such regulatory processes. See related article by Agler, H.L., J. Evans, H.M. Colecraft, D.T. Yue in this issue, pp. 495-510.)

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