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Cover picture: Whole colicin Ia makes an
40 pS channel with four
membrane-spanning segments. If upstream T and R domains
are removed, the first membrane-spanning segment (H1)can move across the
membrane, resulting in a transition from the 40 pS
to an 7 pS channel with only three
membrane-spanning segments.
See related article by Kienker, P.K., K.S. Jakes, R.O.
Blaustein, C. Miller, and A. Finkelstein in this issue,
pp. 161–176.
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