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Cover picture: A possible mechanism for the lock-closed effect of Cd2+ ions on spHCN Q468C. (Left) The KcsA backbone structure with the equivalent positions for spHCN 462 (as histidine),466 (as cysteine),and 468 (as cysteine). (Right) The inner helices in the KcsA structure from the intracellular side,with the homologous position V115 mutated to cysteine in all four subunits. Carbon, white; sulfur,grey; Cd2+, black. See related article by Rothberg, B.S., K. Soon Shin, and G. Yellen, pp. 501-510.
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