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Cover picture: Ca2+ sparks evoked by two photon fl ash photolysis in smooth muscle. Top images show confocal linescan recording during repeated exposure of a urinary bladder myocyte to 730 nm laser illumination (red bars). At the bottom, a similar experiment shows a decrease in delay to Ca2+ release in FKBP12.6 knockout cells (see article by Ji et al., 225-235).
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